U.S. Interagency Autism Coordinating Committee issues, "2009 Summary of Advances in Autism Spectrum Disorder Research"

The Interagency Autism Coordinating Committee (IACC), the body established in accordance with the Combating Autism Act of 2006 (P.L. 109-416), and whose charge is to

"coordinate all efforts within the Department of Health and Human Services concerning autism spectrum disorder to combat autism through research, screening, intervention and education. The Committee’s primary mission is to facilitate the efficient and effective exchange of information on autism activities among the member agencies, and to coordinate autism-related programs and initiatives"

has issued a new report,

2009 Summary of Advances in Autism Spectrum Disorder Research

in which the IACC identifies what they have selected as the twenty top studies from the peer-reviewed literature of 2009 providing significant insight into prevalence, biology, potential risk factors and possible interventions related to autism spectrum disorders.

The current report has a somewhat different format than the prior reports of 2008 and 2007 in being more of a list of articles than a background document.

The twenty articles selected for 2009 from the 63 nominated are,

1. Aman, M.G., McDougle, C.J., Scahill, L., Handen, B., Arnold, L.E., Johnson, C,, et al. (2009).. Medication and parent training in children with pervasive developmental disorders and serious behavior problems: results from a randomized clinical trial. Journal of the American Academy of Child and Adolescent Psychiatry, 48(12),1143-1154.
2. Atladóttir, H.O., Pedersen, M.G., Thorsen, P., Mortensen, P.B., Deleuran, B., Eaton, W.W., et al.(2009). Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics, 124(2):687-94.
3. Bucan, M., Abrahams, B.S., Wang, K., Glessner. J.T., Herman, E.I., Sonnenblick, L.I., et al. (2009). Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. Public Library of Science Genetics., 5(6):e1000536.
4. Centers for Disease Control and Prevention (CDC); Autism and Developmental Disabilities Monitoring Network Surveillance Year 2006 Principal Investigators.(2009).  Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, United States, 2006. Morbidity and Mortality Weekly Report Surveillance Summaries, 58(10), 1-20.
5. Glessner, J.T., Wang, K., Cai, G., Korvatska, O., Kim, C.E., Wood, S., et al. (2009). Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature, 459(7246), 569-73.
6. Gregory, S.G., Connelly, J.J., Towers, A.J., Johnson, J., Biscocho, D., Markunas, C.A., et.al. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Medicine, 7:62.
7. Grether JK, Anderson MC, Croen LA, Smith D, Windham GC. (2009). Risk of autism and increasing maternal and paternal age in a large North American population. American Journal of Epidemiology, 170(9):1118-26.
8. Haswell, C.C., Izawa, J., Dowell, L.R., Mostofsky, S.H., & Shadmehr, R.(2009). Representation of internal models of action in the autistic brain. Nature Neuroscience,12(8),970-2.
9. Ibrahim, S.H., Voigt, R.G., Katusic, S.K., Weaver, A.L., & Barbaresi, W.J.(2009). Incidence of gastrointestinal symptoms in children with autism: a population-based study. Pediatrics,124(2), 680-6.
10. King M, Bearman P. Diagnostic change and the increased prevalence of autism. International Journal of Epidemiology, 38(5),1224-34.
11. Klin, A., Lin, D.J., Gorrindo, P., Ramsay, G.,& Jones, W. (2009). Two-year-olds with autism orient to non-social contingencies rather than biological motion. Nature. 459(7244), 257-61.
12. Kogan, M.D., Blumberg, S.J., Schieve, L.A., Boyle, C.A., Perrin, J.M., Ghandour, R.M., et al. (2009). Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007. Pediatrics, 124(5), 1395-403.
13. Mandell, D.S., Wiggin,s L.D., Carpenter, L.A., Daniels, J., DiGuiseppi, C., Durkin, M.S., et al. (2009). Racial/ethnic disparities in the identification of children with autism spectrum disorders. American Journal of Public Health, 99(3), 493-8.
14. Nakatani, J., Tamada, K., Hatanaka, F., Ise, S., Ohta, H., Inoue, K., et al (2009). Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell, 137(7),1235-46.
15. Ramocki, M.B., Peters, S.U., Tavyev, Y.J., Zhang, F., Carvalho, C.M., Schaaf, C.P., et al. (2009). Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome. Annals of Neurology. 66(6),771-82.
16. Shattuck, P.T., Durkin, M., Maenner, M., Newschaffer, C., Mandell, D.S., Wiggins, L., et al. (2009). Timing of identification among children with an autism spectrum disorder: findings from a population-based surveillance study. Journal of the American Academy of Child and Adolescent Psychiatry, 48(5), 474-83.
17. Tropea, D., Giacometti, E., Wilson, N.R., Beard, C., McCurry C., Fu, D.D., et al. (2009). Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. Proceedings of the National Academy of Sciences, U S A., 106(6), 2029-34.
18. Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J.T., Abrahams, B.S., et al. (2009). Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature. 459(7246),528-33.
19. Weiss, L.A., Arking, D.E., Gene Discovery Project of Johns Hopkins & the Autism Consortium, Daly, M.J., & Chakravarti, A. (2009). A genome-wide linkage and association scan reveals novel loci for autism. Nature, 461(7265),802-8.
20. Zwaigenbaum, L., Bryson, S., Lord, C., Rogers, S., Carter, A., Carver, L., et al. (2009). Clinical assessment and management of toddlers with suspected autism spectrum disorder: insights from studies of high-risk infants. Pediatrics, 123(5),1383-91.

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© 2010 Regina G. Claypool-Frey
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